o

School ofMathematical and Statistical Sciences

Computational and Applied Math Seminar

Friday, February 3, 12:00 p.m. GWC 487

Ming-Hung Kao

School of Mathematical and Statistical Sciences

Experimental Designs for Event-Related fMRI Studies

Abstract Well planned experimental designs are crucially important to successfully achieving statistical goals under practical restrictions in event-related functional magnetic resonance imaging (ER-fMRI) studies. With carefully determined order and onset times of mental stimuli, researchers can acquire informative fMRI time series and render precise and valid statistical inference about functions of our brains. However, due to the complex nature of ER-fMRI, obtaining an optimal ER-fMRI design is an arduous task. While attaining high statistical efficiencies is important, the selected designs should also satisfy some psychological constraints. In addition, the developed approaches for obtaining optimal design should be versatile to accommodate a wide variety of experimental settings considered in practice. In this talk, an introduction to ER-fMRI design problems will be provided. Some of our recent studies on this emerging research area and future research questions will also be discussed.